Comparison · NCT00668434-sae
Prednisone vs Placebo: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Prednisone vs Placebo: serious adverse events. Trial comparisons, record NCT00668434-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00668434-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0166 | 0.00565 | 0.0476 | wilson | |
| Risk in group 2 | 0.0227 | 0.00625 | 0.0791 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00615 | -0.0636 | 0.029 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.729 | 0.124 | 4.29 | log | |
| Odds ratio, group 1 over group 2 | 0.725 | 0.119 | 4.42 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Prednisone than on Placebo | 163 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Prednisone | Participants will receive a 15-day tapering course of prednisone capsules.~Prednisone: For participants who weigh 50 kg or more, the prednisone dose will be 60 mg daily for 5 days, then 40 mg daily for 5 days, and then 20 mg daily for 5 days. For participants who weigh less than 50 kg, the dose will be 40 mg daily for 10 days, and then 20 mg daily for 5 days. | 3 | 181 | EG000 |
| Group 2 | Placebo | Participants will receive a 15-day course of placebo capsules.~Placebo: Placebo capsules will look the same as the study medication but will not contain active medicine. | 2 | 88 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Entire study period, up to 52 weeks
Source ClinicalTrials.gov
Trial
- Title
- Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica
- NCT number
- NCT00668434
- Phases
- PHASE2
- Conditions
- Sciatica
- Interventions
- Prednisone, Placebo
- Lead sponsor
- Kaiser Permanente
- Results first posted
- 2015-04-28
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00668434?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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