Comparison · NCT00679055-sae
MK-0736 vs Placebo: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. MK-0736 vs Placebo: serious adverse events. Trial comparisons, record NCT00679055-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00679055-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.125 | 0.0224 | 0.471 | wilson | |
| Risk in group 2 | 0.167 | 0.0301 | 0.564 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0417 | -0.452 | 0.33 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.75 | 0.0579 | 9.72 | log | |
| Odds ratio, group 1 over group 2 | 0.714 | 0.0356 | 14.3 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on MK-0736 than on Placebo | 24 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | MK-0736 | Participants will be orally administered 7 mg of MK-0736 once daily for 12 weeks | 1 | 8 | EG000 |
| Group 2 | Placebo | Participants will be orally administered placebo once daily for 12 weeks. | 1 | 6 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- up to 14 weeks
Source ClinicalTrials.gov
Trial
- Title
- A Study of How MK-0736 Affects Arterial Plaque (0736-006)(TERMINATED)
- NCT number
- NCT00679055
- Phases
- PHASE1
- Conditions
- Peripheral Vascular Diseases
- Interventions
- MK-0736, Comparator: placebo (unspecified)
- Lead sponsor
- Merck Sharp & Dohme LLC
- Results first posted
- 2015-02-16
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00679055?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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