Comparison · NCT00699153-b7fb48b1
Loteprednol Etabonate vs Vehicle: Participants With Complete Resolution of Anterior Chamber Cells and Flare. Grade=0
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Loteprednol Etabonate vs Vehicle: Participants With Complete Resolution of Anterior Chamber Cells and Flare. Grade=0. Trial comparisons, record NCT00699153-b7fb48b1. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00699153-b7fb48b1
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.315 | 0.255 | 0.382 | wilson | |
| Risk in group 2 | 0.114 | 0.0771 | 0.165 | wilson | |
| Risk difference, group 1 minus group 2 | 0.201 | 0.123 | 0.278 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 2.77 | 1.79 | 4.28 | log | |
| Odds ratio, group 1 over group 2 | 3.58 | 2.12 | 6.06 | log | |
| Number needed to treat, for one more participant with the outcome on Loteprednol Etabonate than on Vehicle | 4.97 | 3.6 | 8.16 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: vehicle.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Loteprednol Etabonate | Loteprednol Etabonate Ophthalmic Ointment 0.5% | 64 | 203 | OG000 |
| Group 2 | Vehicle | Vehicle of Ophthalmic Loteprednol Etabonate | 23 | 202 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Participants With Complete Resolution of Anterior Chamber Cells and Flare. Grade=0
- Description
A combination of the grades for inflammatory cells and flare in the anterior chamber. Cells: accumulation of white blood cells in aqueous. 0=No cells seen; 1=1-5 cells; 2=6-15 cells; 3=16-30 cells; 4= \>30 cells. Flare: Scattering of a slit lamp light beam when directed into the anterior chamber (Tyndall effect). 0=None; 1=Mild; 2=Moderate; 3=Severe; 4=Very severe.
- Time frame
- Postoperative day 8 (Visit 5)
- Population
- Intent to treat population, subjects who had missing data or took rescue medication prior to visit 5 were imputed as no.
Source ClinicalTrials.gov
Trial
- Title
- Loteprednol Etabonate in an Ophthalmic Base vs Vehicle for the Treatment of Inflammation Following Cataract Surgery
- NCT number
- NCT00699153
- Phases
- PHASE3
- Conditions
- Ocular Inflammation
- Interventions
- Loteprednol Etabonate, Vehicle of Ophthalmic Loteprednol Etabonate
- Lead sponsor
- Bausch & Lomb Incorporated
- Results first posted
- 2010-09-23
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00699153?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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