Active Vitamin E vs Vitamin E Placebo: Effect of Vitamin E on CRA Occurrence, Analyzed by Active Vitamin E vs. Vitamin E Placebo
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.355 | 0.338 | 0.371 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.344 | 0.328 | 0.36 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | 0.0106 | -0.0125 | 0.0337 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 1.03 | 0.965 | 1.1 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 1.05 | 0.947 | 1.16 | log | ClinicalTrials.gov | |
| Number needed to treat, for one more participant with the outcome on Active Vitamin E than on Vitamin E Placebo | 94.1 | from the risk difference interval | the interval includes no difference | ClinicalTrials.gov |
Groups 2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | Active Vitamin E | Active vitamin E +/- selenium | 1,159 | 3,269 | OG000 | ClinicalTrials.gov |
| Group 2 | Vitamin E Placebo | Vitamin E placebo +/- selenium | 1,127 | 3,277 | OG001 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | SECONDARY | ClinicalTrials.gov |
| Title | Effect of Vitamin E on CRA Occurrence, Analyzed by Active Vitamin E vs. Vitamin E Placebo | ClinicalTrials.gov |
| Description | ClinicalTrials.gov | |
| Time frame | From 1 year post randomization through study completion | ClinicalTrials.gov |
| Population | Marginal analyses were performed, with arms pooled based on active vs. placebo Vitamin E. | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000 | ClinicalTrials.gov |
| NCT number | NCT00706121 | ClinicalTrials.gov |
| Phases | PHASE3 | ClinicalTrials.gov |
| Conditions | Colorectal Cancer, Precancerous Condition | ClinicalTrials.gov |
| Interventions | Vitamin E, Selenium, Vitamin E placebo, selenium placebo | ClinicalTrials.gov |
| Lead sponsor | SWOG Cancer Research Network | ClinicalTrials.gov |
| Results first posted | 2017-04-04 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT00706121?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.