Active Selenium vs Selenium Placebo: Effect of Selenium on Colorectal Adenoma (CRA) Occurrence, Analyzed by Active Selenium vs. Selenium Placebo
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.342 | 0.326 | 0.358 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.357 | 0.341 | 0.374 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | -0.0156 | -0.0387 | 0.0075 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 0.956 | 0.895 | 1.02 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 0.934 | 0.843 | 1.03 | log | ClinicalTrials.gov | |
| Number needed to treat, for one fewer participant with the outcome on Active Selenium than on Selenium Placebo | 64.1 | from the risk difference interval | the interval includes no difference | ClinicalTrials.gov |
Groups 2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | Active Selenium | Active Selenium +/- Vitamin E | 1,136 | 3,326 | OG000 | ClinicalTrials.gov |
| Group 2 | Selenium Placebo | Selenium Placebo +/- Vitamin E | 1,150 | 3,220 | OG001 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | PRIMARY | ClinicalTrials.gov |
| Title | Effect of Selenium on Colorectal Adenoma (CRA) Occurrence, Analyzed by Active Selenium vs. Selenium Placebo | ClinicalTrials.gov |
| Description | ClinicalTrials.gov | |
| Time frame | From 1 year post randomization through study completion | ClinicalTrials.gov |
| Population | Marginal analyses were performed, with arms pooled based on active vs. placebo selenium. | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000 | ClinicalTrials.gov |
| NCT number | NCT00706121 | ClinicalTrials.gov |
| Phases | PHASE3 | ClinicalTrials.gov |
| Conditions | Colorectal Cancer, Precancerous Condition | ClinicalTrials.gov |
| Interventions | Vitamin E, Selenium, Vitamin E placebo, selenium placebo | ClinicalTrials.gov |
| Lead sponsor | SWOG Cancer Research Network | ClinicalTrials.gov |
| Results first posted | 2017-04-04 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT00706121?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.