Comparison · NCT00784810-sae
Oxycodone/Naloxone Tablets (OXN) vs Codeine/Paracetamol Tablets: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Oxycodone/Naloxone Tablets (OXN) vs Codeine/Paracetamol Tablets: serious adverse events. Trial comparisons, record NCT00784810-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00784810-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0242 | 0.00826 | 0.0687 | wilson | |
| Risk in group 2 | 0.0325 | 0.0127 | 0.0806 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00833 | -0.059 | 0.0404 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.744 | 0.17 | 3.26 | log | |
| Odds ratio, group 1 over group 2 | 0.738 | 0.162 | 3.37 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Oxycodone/Naloxone Tablets (OXN) than on Codeine/Paracetamol Tablets | 120 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Oxycodone/Naloxone Tablets (OXN) | Oxycodone/Naloxone (OXN) tablets 5,10 and 20 mg | 3 | 124 | EG000 |
| Group 2 | Codeine/Paracetamol Tablets | Codeine/Paracetamol 15/500 and 30/500 mg | 4 | 123 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- approximately 3 - 4 months, treatment and outcome
Source ClinicalTrials.gov
Trial
- Title
- A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to Osteoarthritis
- NCT number
- NCT00784810
- Phases
- PHASE4
- Conditions
- Osteoarthritis, Back Pain
- Interventions
- Oxycodone/Naloxone, Codeine/Paracetamol
- Lead sponsor
- Napp Pharmaceuticals Limited
- Results first posted
- 2011-11-02
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00784810?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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