Comparison · NCT00809055-167f0970
High Dose Caffeine vs Standard Dose Caffeine: Rates of Chronic Lung Disease
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. High Dose Caffeine vs Standard Dose Caffeine: Rates of Chronic Lung Disease. Trial comparisons, record NCT00809055-167f0970. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00809055-167f0970
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.514 | 0.359 | 0.666 | wilson | |
| Risk in group 2 | 0.486 | 0.334 | 0.641 | wilson | |
| Risk difference, group 1 minus group 2 | 0.027 | -0.192 | 0.242 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.06 | 0.669 | 1.67 | log | |
| Odds ratio, group 1 over group 2 | 1.11 | 0.448 | 2.77 | log | |
| Number needed to treat, for one more participant with the outcome on High Dose Caffeine than on Standard Dose Caffeine | 37 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | High Dose Caffeine | Loading dose 40mg/kg IV caffeine citrate, followed 12 hours later by 20mg/kg IV caffeine citrate, followed 12 hours later by 10mg/kg IV caffeine citrate, followed 12 hours later by 10mg/kg IV caffeine citrate.~Caffeine citrate: Caffeine to be administered as outlined to compare efficacy of different dosages. | 19 | 37 | OG000 |
| Group 2 | Standard Dose Caffeine | Loading dose 20mg/kg IV caffeine citrate, followed 12 hours later with D5W placebo, followed 12 hours later with 10mg/kg IV caffeine citrate, followed 12 hours later with D5W placebo.~Caffeine citrate: Caffeine to be administered as outlined to compare efficacy of different dosages. | 18 | 37 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Rates of Chronic Lung Disease
- Description
- Defined as oxygen requirement at 36 weeks PMA
- Time frame
- Participants were followed for the duration of hospital stay, an average of 12 weeks
- Population
Source ClinicalTrials.gov
Trial
- Title
- MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine
- NCT number
- NCT00809055
- Phases
- PHASE4
- Conditions
- Apnea of Prematurity, Intraventricular Hemorrhage, Brain Injury
- Interventions
- Caffeine citrate
- Lead sponsor
- Washington University School of Medicine
- Results first posted
- 2016-02-24
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00809055?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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