Comparison · NCT00817063-sae
Alitretinoin 30 mg vs Placebo: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Alitretinoin 30 mg vs Placebo: serious adverse events. Trial comparisons, record NCT00817063-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00817063-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0236 | 0.0115 | 0.048 | wilson | |
| Risk in group 2 | 0.0101 | 0.00343 | 0.0292 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0136 | -0.00906 | 0.0388 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 2.35 | 0.613 | 9 | log | |
| Odds ratio, group 1 over group 2 | 2.38 | 0.61 | 9.3 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Alitretinoin 30 mg than on Placebo | 73.6 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Alitretinoin 30 mg | Participants with severe CHE rated as refractory during the run-in period were randomized to receive 30 mg of alitretinoin oral soft capsule once daily up to 24 weeks. | 7 | 296 | EG000 |
| Group 2 | Placebo | Participants with severe CHE rated as refractory during the run-in period were randomized to receive matching Placebo oral soft capsule once daily up to 24 weeks. | 3 | 298 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- AEs were collected up to follow up period (up to Week 28). Treatment emergent SAEs and nSAEs (up to Week 24) has been presented.
Source ClinicalTrials.gov
Trial
- Title
- Efficacy and Safety of a Retinoid in the Treatment of Severe Chronic Hand Eczema
- NCT number
- NCT00817063
- Phases
- PHASE3
- Conditions
- Eczema
- Interventions
- alitretinoin, Placebo
- Lead sponsor
- Stiefel, a GSK Company
- Results first posted
- 2017-11-09
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00817063?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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