Comparison · NCT00894387-0d655263
Aliskiren vs Placebo: Time to Event Analysis: Number of Patients With All-cause Mortality Hospitalized for an AHF Event Within 12 Months
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Aliskiren vs Placebo: Time to Event Analysis: Number of Patients With All-cause Mortality Hospitalized for an AHF Event Within 12 Months. Trial comparisons, record NCT00894387-0d655263. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00894387-0d655263
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.178 | 0.153 | 0.206 | wilson | |
| Risk in group 2 | 0.183 | 0.158 | 0.212 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00518 | -0.0427 | 0.0324 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.972 | 0.79 | 1.2 | log | |
| Odds ratio, group 1 over group 2 | 0.966 | 0.749 | 1.24 | log | |
| Number needed to treat, for one fewer participant with the outcome on Aliskiren than on Placebo | 193 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Aliskiren | Randomized patients in this arm received, Aliskiren 150 mg once daily for 2 weeks. From week 2 upto 6 months , patients who could tolerate study medication were up-titrated to aliskiren 300 mg once daliy. | 144 | 808 | OG000 |
| Group 2 | Placebo | Randomized patients in this arm received matching placebo of Aliskiren. At week 2, Patients who could tolerate study medication were up-titrated to matching placebo of 300 mg aliskiren. | 148 | 807 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Time to Event Analysis: Number of Patients With All-cause Mortality Hospitalized for an AHF Event Within 12 Months
- Description
- Time frame
- 12 months
- Population
- Full ananlysis set included all randomized patients who had at least one dose of study drug.
Source ClinicalTrials.gov
Trial
- Title
- Six Months Efficacy and Safety of Aliskiren Therapy on Top of Standard Therapy, on Morbidity and Mortality in Patients With Acute Decompensated Heart Failure
- NCT number
- NCT00894387
- Phases
- PHASE3
- Conditions
- Acute Decompensated Heart Failure, Congestive Heart Failure
- Interventions
- Aliskiren, Placebo
- Lead sponsor
- Novartis Pharmaceuticals
- Results first posted
- 2013-10-10
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00894387?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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