Comparison · NCT00920140-sae
GSK1120212 <2 mg OD vs GSK1120212 2 mg OD: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. GSK1120212 <2 mg OD vs GSK1120212 2 mg OD: serious adverse events. Trial comparisons, record NCT00920140-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00920140-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.333 | 0.0968 | 0.7 | wilson | |
| Risk in group 2 | 0.703 | 0.603 | 0.787 | wilson | |
| Risk difference, group 1 minus group 2 | -0.37 | -0.621 | 0.0102 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.474 | 0.152 | 1.48 | log | |
| Odds ratio, group 1 over group 2 | 0.211 | 0.0364 | 1.22 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on GSK1120212 <2 mg OD than on GSK1120212 2 mg OD | 2.7 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | GSK1120212 <2 mg OD | Participants with relapsed or refractory leukemias received either GSK1120212 3 mg LD followed by 1 mg OD (3/1 mg LD/OD), or 1 mg OD as a continuous dose. | 2 | 6 | EG000 |
| Group 2 | GSK1120212 2 mg OD | Participants with relapsed or refractory leukemias received GSK1120212 2 mg OD as a continuous dose. | 64 | 91 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Serious adverse events (SAEs) and non-serious AEs were collected from the start of study drug until the final study visit (up to approximately 407 days).
Source ClinicalTrials.gov
Trial
- Title
- Open-label Study to Evaluate the Safety, PK, and PD of MEK Inhibitor GSK1120212 in Subjects With Relapsed or Refractory Leukemias
- NCT number
- NCT00920140
- Phases
- PHASE2
- Conditions
- Cancer
- Interventions
- GSK1120212, GSK1120212
- Lead sponsor
- GlaxoSmithKline
- Results first posted
- 2014-02-28
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00920140?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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