Comparison · NCT00927953-71bd8a18
MGAWN1 vs Placebo - Normal Saline: The Number of Participants Who Had At Least 1 Treatment-Related Adverse Event
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. MGAWN1 vs Placebo - Normal Saline: The Number of Participants Who Had At Least 1 Treatment-Related Adverse Event. Trial comparisons, record NCT00927953-71bd8a18. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00927953-71bd8a18
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0 | 0.0000000000000000278 | 0.39 | wilson | |
| Risk in group 2 | 0.429 | 0.158 | 0.75 | wilson | |
| Risk difference, group 1 minus group 2 | -0.429 | -0.75 | 0.0462 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat, for one fewer participant with the outcome on MGAWN1 than on Placebo - Normal Saline | 2.33 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | MGAWN1 | 30 mg/kg single intravenous infusion of MGAWN1 | 0 | 6 | OG000 |
| Group 2 | Placebo - Normal Saline | single intravenous infusion of saline placebo | 3 | 7 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- The Number of Participants Who Had At Least 1 Treatment-Related Adverse Event
- Description
- Includes adverse events considered possibly, probably, or definitely related to study drug
- Time frame
- 120 days
- Population
- Intention to treat (ITT)
Source ClinicalTrials.gov
Trial
- Title
- Treatment of West Nile Virus With MGAWN1
- NCT number
- NCT00927953
- Phases
- PHASE2
- Conditions
- West Nile Neuroinvasive Disease, West Nile Virus Infection, Encephalitis, Meningitis, Acute Flaccid Paralysis, West Nile Fever
- Interventions
- MGAWN1, Placebo - normal saline
- Lead sponsor
- MacroGenics
- Results first posted
- 2012-11-07
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00927953?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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