Comparison · NCT00929162-2fcc4a6b
ZD4054+Paclitaxel+Carboplatin vs Placebo+Paclitaxel+Carboplatin: Tumour Response Rate
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. ZD4054+Paclitaxel+Carboplatin vs Placebo+Paclitaxel+Carboplatin: Tumour Response Rate. Trial comparisons, record NCT00929162-2fcc4a6b. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00929162-2fcc4a6b
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.382 | 0.265 | 0.514 | wilson | |
| Risk in group 2 | 0.586 | 0.458 | 0.704 | wilson | |
| Risk difference, group 1 minus group 2 | -0.204 | -0.37 | -0.0203 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.651 | 0.437 | 0.971 | log | |
| Odds ratio, group 1 over group 2 | 0.436 | 0.205 | 0.927 | log | |
| Number needed to treat, for one fewer participant with the outcome on ZD4054+Paclitaxel+Carboplatin than on Placebo+Paclitaxel+Carboplatin | 4.89 | 2.7 | 49.3 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | ZD4054+Paclitaxel+Carboplatin | ZD4054 10mg oral tablet once daily + paclitaxel +carboplatin intravenous infusions every 3 weeks | 21 | 55 | OG000 |
| Group 2 | Placebo+Paclitaxel+Carboplatin | Placebo oral tablet once daily + paclitaxel +carboplatin intravenous infusions every 3 weeks | 34 | 58 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Tumour Response Rate
- Description
- Objective response rate defined as participants with a complete or partial response according to RECIST
- Time frame
- While receiving paclitaxel + carboplatin study visits were aliged with its administration ie every 3 weeks, then every 6 weeks (up to 2 years)
- Population
- The number of participants for analysis corresponds to patients with measurable disease at study entry
Source ClinicalTrials.gov
Trial
- Title
- ZD4054 (Zibotentan) or Placebo Plus Chemotherapy in Patients With Advanced Ovarian Cancer
- NCT number
- NCT00929162
- Phases
- PHASE2
- Conditions
- Patients With Advanced Ovarian Cancer Sensitive to Platinum-based Chemotherapy
- Interventions
- ZD4054 Zibotentan, Paclitaxel, Carboplatin, Placebo
- Lead sponsor
- AstraZeneca
- Results first posted
- 2012-06-06
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00929162?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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