Comparison · NCT00953927-9eb1a003
Investigational Vaccine vs Control Group: To Evaluate the QuantiFERON Conversion Rate at Final Study Assessment in MVA85A/AERAS-485 Recipients Compared to Controls in Infants Without a Diagnosis of Tuberculosis During the Trial.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Investigational Vaccine vs Control Group: To Evaluate the QuantiFERON Conversion Rate at Final Study Assessment in MVA85A/AERAS-485 Recipients Compared to Controls in Infants Without a Diagnosis of Tuberculosis During the Trial. Trial comparisons, record NCT00953927-9eb1a003. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00953927-9eb1a003
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.127 | 0.111 | 0.146 | wilson | |
| Risk in group 2 | 0.123 | 0.106 | 0.141 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00466 | -0.0199 | 0.0292 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.04 | 0.853 | 1.26 | log | |
| Odds ratio, group 1 over group 2 | 1.04 | 0.834 | 1.31 | log | |
| Number needed to treat, for one more participant with the outcome on Investigational Vaccine than on Control Group | 215 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: control.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Investigational Vaccine | MVA85A/AERAS-485; subset into cohorts to explore different safety and immunogenicity tests. | 178 | 1,398 | OG000 |
| Group 2 | Control Group | Candida Skin Test Antigen control; subset into cohorts to explore different safety and immunogenicity tests. | 171 | 1,394 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- To Evaluate the QuantiFERON Conversion Rate at Final Study Assessment in MVA85A/AERAS-485 Recipients Compared to Controls in Infants Without a Diagnosis of Tuberculosis During the Trial.
- Description
- The number (percentage) of infants with QuantiFERON conversions at any time on the study were summarized by treatment group.
- Time frame
- 15 to 36 months post-vaccination
- Population
- Per protocol population who were quantiferon negative at baseline.
Source ClinicalTrials.gov
Trial
- Title
- A Study of MVA85A in Healthy Infants
- NCT number
- NCT00953927
- Phases
- PHASE2
- Conditions
- Tuberculosis
- Interventions
- MVA85A/AERAS-485, Candida Skin Test Antigen
- Lead sponsor
- Aeras
- Results first posted
- 2013-12-12
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00953927?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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