Comparison · NCT00988208-sae
Docetaxel/Prednisone/Lenalidomide (DPL) vs Docetaxel/ Prednisone/and Placebo (DP): serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Docetaxel/Prednisone/Lenalidomide (DPL) vs Docetaxel/ Prednisone/and Placebo (DP): serious adverse events. Trial comparisons, record NCT00988208-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00988208-sae
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.539 | 0.496 | 0.581 | wilson | |
| Risk in group 2 | 0.338 | 0.299 | 0.379 | wilson | |
| Risk difference, group 1 minus group 2 | 0.201 | 0.142 | 0.259 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.6 | 1.38 | 1.84 | log | |
| Odds ratio, group 1 over group 2 | 2.29 | 1.79 | 2.94 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Docetaxel/Prednisone/Lenalidomide (DPL) than on Docetaxel/ Prednisone/and Placebo (DP) | 4.97 | 3.86 | 7.07 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Docetaxel/Prednisone/Lenalidomide (DPL) | Participants received docetaxel 75 mg/m\^2 by intravenous (IV) administration over 60 minutes on Day 1, prednisone 5 mg orally twice a day (BID) and lenalidomide 25 mg capsules daily (QD) on Days 1-14 in each 21-day treatment cycle. | 283 | 525 | EG000 |
| Group 2 | Docetaxel/ Prednisone/and Placebo (DP) | Participants received Docetaxel 75 mg/m\^2 by intravenous (IV) administration over 30-60 minutes on Day 1, Prednisone 5 mg orally twice a day (BID) and identically matching placebo capsules daily (QD) on Days 1-14 in each 21-day treatment cycle. | 176 | 521 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
From first dose of study treatment to 28 days after the last dose; as of the final analysis cut-off of 20 April 2017; median overall duration of treatment was 22.1 months for DPL and 27.0 months for the DP group
Source ClinicalTrials.gov
Trial
- Title
- Study to Evaluate Safety and Effectiveness of Lenalidomide in Combination With Docetaxel and Prednisone for Patients With Castrate-Resistant Prostate Cancer
- NCT number
- NCT00988208
- Phases
- PHASE3
- Conditions
- Prostate Cancer
- Interventions
- Lenalidomide, Docetaxel, Prednisone, Placebo
- Lead sponsor
- Celgene
- Results first posted
- 2013-09-05
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00988208?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT00988208-sae