Comparison · NCT01083576-813de5be
Paromomycin Alone Treatment vs WR 279,396: Number of Participants Who Obtained Final Clinical Cure of Index Lesion
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Paromomycin Alone Treatment vs WR 279,396: Number of Participants Who Obtained Final Clinical Cure of Index Lesion. Trial comparisons, record NCT01083576-813de5be. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01083576-813de5be
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.6 | 0.357 | 0.802 | wilson | |
| Risk in group 2 | 0.867 | 0.621 | 0.963 | wilson | |
| Risk difference, group 1 minus group 2 | -0.267 | -0.527 | 0.0511 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.692 | 0.438 | 1.09 | log | |
| Odds ratio, group 1 over group 2 | 0.231 | 0.0377 | 1.41 | log | |
| Number needed to treat, for one fewer participant with the outcome on Paromomycin Alone Treatment than on WR 279,396 | 3.75 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Paromomycin Alone Treatment | Paromomycin Alone Cream (15% paromomycin topical cream): topical application to uncomplicated CL lesions once daily for 20 days | 9 | 15 | OG000 |
| Group 2 | WR 279,396 | WR 279,396 (15% paromomycin + 0.5% gentamicin topical cream): topical application to uncomplicated CL lesions once daily for 20 days | 13 | 15 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants Who Obtained Final Clinical Cure of Index Lesion
- Description
Number of participants who had initial clinical cure (100% re-epithelialization of index lesion by Day 63) OR initial clinical improvements (\> 50% re-epithelialization of index lesion followed by Day 63 by 100% re-epithelialization of the index lesion on or before Day 100), AND no relapse of index lesion.
- Time frame
- 168 days
- Population
- All randomized subjects were included in the mITT Analysis. All subjects met criteria for the evaluable subset.
Source ClinicalTrials.gov
Trial
- Title
- Pharmacokinetics, Safety, and Efficacy Trial of WR 279,396 (Paromomycin + Gentamicin Topical Cream) and Paromomycin Topical Cream for the Treatment of Cutaneous Leishmaniasis in Panama
- NCT number
- NCT01083576
- Phases
- PHASE2
- Conditions
- Leishmaniasis, Cutaneous
- Interventions
- WR 279,396 (15% paromomycin + 0.5% gentamicin topical cream), Paromomycin Alone Cream (15% paromomycin topical cream)
- Lead sponsor
- U.S. Army Medical Research and Development Command
- Results first posted
- 2014-05-15
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01083576?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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