Comparison · NCT01189890-sae
Sitagliptin vs Glimepiride: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Sitagliptin vs Glimepiride: serious adverse events. Trial comparisons, record NCT01189890-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01189890-sae
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.029 | 0.0141 | 0.0587 | wilson | |
| Risk in group 2 | 0.0254 | 0.0117 | 0.0543 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00362 | -0.0289 | 0.0363 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.14 | 0.39 | 3.35 | log | |
| Odds ratio, group 1 over group 2 | 1.15 | 0.38 | 3.46 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Sitagliptin than on Glimepiride | 276 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Sitagliptin | Sitagliptin phosphate 100 mg once daily (QD) or 50 mg QD | 7 | 241 | EG000 |
| Group 2 | Glimepiride | Glimepiride 1-6 mg QD | 6 | 236 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Up to Week 32.
Source ClinicalTrials.gov
Trial
- Title
- Safety and Efficacy of Sitagliptin Compared With Glimepiride in Elderly Participants With Type 2 Diabetes Mellitus (MK-0431-251)
- NCT number
- NCT01189890
- Phases
- PHASE3
- Conditions
- Type 2 Diabetes Mellitus
- Interventions
- sitagliptin phosphate, Glimepiride, Placebo to Sitagliptin, Placebo to Glimepiride
- Lead sponsor
- Merck Sharp & Dohme LLC
- Results first posted
- 2013-06-27
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01189890?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT01189890-sae