Comparison · NCT01190813-0c0166b3
Levodopa/Carbidopa vs Placebo: Amblyopic Eye Visual Acuity Improvement Treatment Group Comparison at 18 Weeks
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Levodopa/Carbidopa vs Placebo: Amblyopic Eye Visual Acuity Improvement Treatment Group Comparison at 18 Weeks. Trial comparisons, record NCT01190813-0c0166b3. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01190813-0c0166b3
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.151 | 0.0905 | 0.242 | wilson | |
| Risk in group 2 | 0.0444 | 0.0123 | 0.148 | wilson | |
| Risk difference, group 1 minus group 2 | 0.107 | -0.0135 | 0.203 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 3.4 | 0.802 | 14.4 | log | |
| Odds ratio, group 1 over group 2 | 3.83 | 0.824 | 17.8 | log | |
| Number needed to treat, for one more participant with the outcome on Levodopa/Carbidopa than on Placebo | 9.37 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Levodopa/Carbidopa | Levodopa 0.76 mg/kg with Carbidopa 0.17 mg/kg tid~Levodopa/Carbidopa: Oral levodopa 0.76 mg/kg tid with carbidopa 0.17 mg/kg tid~Patching: Two hours of daily patching | 13 | 86 | OG000 |
| Group 2 | Placebo | Oral placebo tid~Placebo: Oral placebo tid~Patching: Two hours of daily patching | 2 | 45 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Amblyopic Eye Visual Acuity Improvement Treatment Group Comparison at 18 Weeks
- Description
- Treatment group comparisons of the proportion of subjects who have improved from baseline by 10 or more letters.
- Time frame
- 18 weeks after enrollment
- Population
The analysis followed the intent-to-treat principle. For missing primary outcome visits (±1 wk), data from a visit 14-27 wks after randomization were used, if available.Multiple imputation(Monte Carlo Markov Chain method) was used for missing 18-wk VA outcomes based on treatment group, baseline VA, and VA scores from completed follow-up visits
Source ClinicalTrials.gov
Trial
- Title
- Levodopa for the Treatment of Residual Amblyopia
- NCT number
- NCT01190813
- Phases
- PHASE3
- Conditions
- Amblyopia
- Interventions
- Levodopa/Carbidopa, Placebo, Patching
- Lead sponsor
- Jaeb Center for Health Research
- Results first posted
- 2015-02-13
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01190813?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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