Comparison · NCT01195636-985b2176
XPF-002 vs Placebo: Proportion of Subjects Achieving 50% Improvement in Mean Daily Pain Score From Baseline to Week 3 on XPF-002 Treatment Compared to Placebo Treatment
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. XPF-002 vs Placebo: Proportion of Subjects Achieving 50% Improvement in Mean Daily Pain Score From Baseline to Week 3 on XPF-002 Treatment Compared to Placebo Treatment. Trial comparisons, record NCT01195636-985b2176. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01195636-985b2176
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.288 | 0.183 | 0.423 | wilson | |
| Risk in group 2 | 0.115 | 0.054 | 0.23 | wilson | |
| Risk difference, group 1 minus group 2 | 0.173 | 0.0177 | 0.321 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 2.5 | 1.05 | 5.94 | log | |
| Odds ratio, group 1 over group 2 | 3.11 | 1.1 | 8.8 | log | |
| Number needed to treat, for one more participant with the outcome on XPF-002 than on Placebo | 5.78 | 3.12 | 56.4 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | XPF-002 | XPF-002: 8% strength ointment, applied twice daily for 3 weeks in either the first intervention period or second intervention period. | 15 | 52 | OG000 |
| Group 2 | Placebo | Placebo: Vehicle only ointment, applied twice daily for 3 weeks in either first intervention period or second intervention period. | 6 | 52 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Proportion of Subjects Achieving 50% Improvement in Mean Daily Pain Score From Baseline to Week 3 on XPF-002 Treatment Compared to Placebo Treatment
- Description
- Time frame
- 3 weeks
- Population
The Efficacy Evaluable Population was used for this analysis. This population includes randomised subjects who recorded both baseline and post-baseline data in both treatment periods.~Missing data were not imputed. Only subjects who recorded sufficient pain scores in each treatment period were included in this analysis.
Source ClinicalTrials.gov
Trial
- Title
- A Crossover Study to Evaluate the Safety, Tolerability and Efficacy of XPF-002 in Subjects With Postherpetic Neuralgia (PHN)
- NCT number
- NCT01195636
- Phases
- PHASE2
- Conditions
- Postherpetic Neuralgia
- Interventions
- XPF-002, Placebo
- Lead sponsor
- Xenon Pharmaceuticals Inc.
- Results first posted
- 2013-11-25
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01195636?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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