Comparison · NCT01222247-2bab6281
Betamethasone vs Placebo: Neonatal Morbidity Composite
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Betamethasone vs Placebo: Neonatal Morbidity Composite. Trial comparisons, record NCT01222247-2bab6281. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01222247-2bab6281
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0568 | 0.0459 | 0.07 | wilson | |
| Risk in group 2 | 0.0643 | 0.0526 | 0.0784 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00752 | -0.0253 | 0.0101 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.883 | 0.66 | 1.18 | log | |
| Odds ratio, group 1 over group 2 | 0.876 | 0.643 | 1.19 | log | |
| Number needed to treat, for one fewer participant with the outcome on Betamethasone than on Placebo | 133 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Betamethasone | A course of two 2mL intramuscular (IM) injections containing 3 mg of betamethasone, 24 hours apart | 81 | 1,427 | OG000 |
| Group 2 | Placebo | A similar course of an identical appearing placebo: two 2 mL IM injections of placebo, 24 hours apart~Placebo: Similar course of identical appearing placebo: 2 mL IM injections, 24 hours apart. | 90 | 1,400 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Neonatal Morbidity Composite
- Description
- A composite endpoint of morbidities known to be affected by steroid administration will also be evaluated. Specifically, this composite will include RDS, intraventricular hemorrhage (IVH), and NEC
- Time frame
- Delivery
- Population
- The number of participants analyzed accounts for the 4 participants for which baseline measures were obtained but who were subsequently lost to follow-up (2 in each group).
Source ClinicalTrials.gov
Trial
- Title
- Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial
- NCT number
- NCT01222247
- Phases
- PHASE3
- Conditions
- Pregnancy, Respiratory Distress Syndrome, Pregnancy Outcomes, Preterm Birth
- Interventions
- Betamethasone, Placebo
- Lead sponsor
- The George Washington University Biostatistics Center
- Results first posted
- 2019-01-30
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01222247?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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