Comparison · NCT01228149-be21dbcc
Diamox/DexaEDO vs Cosopt S: Ocular Hypotension Rate
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Diamox/DexaEDO vs Cosopt S: Ocular Hypotension Rate. Trial comparisons, record NCT01228149-be21dbcc. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01228149-be21dbcc
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.161 | 0.0709 | 0.326 | wilson | |
| Risk in group 2 | 0.111 | 0.0385 | 0.281 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0502 | -0.142 | 0.23 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.45 | 0.382 | 5.52 | log | |
| Odds ratio, group 1 over group 2 | 1.54 | 0.331 | 7.14 | log | |
| Number needed to treat, for one more participant with the outcome on Diamox/DexaEDO than on Cosopt S | 19.9 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Diamox/DexaEDO | Patients receive Diamox (oral acetazolamide) starting 28 days preoperatively. 7 days preoperatively DexaEDO (dexamethasone) eyedrops without preservatives are applied additionally.~Trabeculectomy: Filtrating glaucoma surgery, preoperative treatment will be assessed. | 5 | 31 | OG000 |
| Group 2 | Cosopt S | Patients receive Cosopt S (dorzolamide/timolol) eye drops starting 28 days preoperatively~Trabeculectomy: Filtrating glaucoma surgery, preoperative treatment will be assessed. | 3 | 27 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Ocular Hypotension Rate
- Description
- Ocular hypotension rate (0-5 mmHg of the study eye) indicated by the number of patients with ocular hypertension
- Time frame
- 24 weeks
- Population
- PP Population
Source ClinicalTrials.gov
Trial
- Title
- COSOPT-S® Treatment Versus Acetazolamide Before Trabeculectomy
- NCT number
- NCT01228149
- Phases
- PHASE4
- Conditions
- Glaucoma
- Interventions
- Trabeculectomy with preoperative Diamox/DexaEDO treatment, Trabeculectomy with preoperative Cosopt S treatment
- Lead sponsor
- Katrin Lorenz
- Results first posted
- 2017-04-14
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01228149?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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