Comparison · NCT01232296-sae
TKI258 vs Sorafenib: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. TKI258 vs Sorafenib: serious adverse events. Trial comparisons, record NCT01232296-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01232296-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.506 | 0.398 | 0.614 | wilson | |
| Risk in group 2 | 0.41 | 0.31 | 0.517 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0967 | -0.0557 | 0.243 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.24 | 0.882 | 1.73 | log | |
| Odds ratio, group 1 over group 2 | 1.48 | 0.794 | 2.75 | log | |
| Number needed to harm, for one more participant with a serious adverse event on TKI258 than on Sorafenib | 10.3 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | TKI258 | 500 mg capsules p.o. o.d. 5 days on/2 days off | 40 | 79 | EG000 |
| Group 2 | Sorafenib | 400 mg tablet p.o. b.i.d. | 34 | 83 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
Source ClinicalTrials.gov
Trial
- Title
- A Study of Dovitinib Versus Sorafenib in Adult Patients With Hepatocellular Carcinoma (HCC) as a First Line Treatment
- NCT number
- NCT01232296
- Phases
- PHASE2
- Conditions
- Hepatocellular Carcinoma
- Interventions
- dovitinib, sorafenib
- Lead sponsor
- Novartis Pharmaceuticals
- Results first posted
- 2015-12-04
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01232296?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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