Comparison · NCT01392183-deaths
Temsirolimus (Control Group) vs Pazopanib (Treatment Group): deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Temsirolimus (Control Group) vs Pazopanib (Treatment Group): deaths from any cause. Trial comparisons, record NCT01392183-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01392183-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.64 | 0.501 | 0.759 | wilson | |
| Risk in group 2 | 0.564 | 0.433 | 0.686 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0764 | -0.109 | 0.253 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.14 | 0.831 | 1.55 | log | |
| Odds ratio, group 1 over group 2 | 1.38 | 0.627 | 3.02 | log | |
| Number needed to harm, for one more death from any cause on Temsirolimus (Control Group) than on Pazopanib (Treatment Group) | 13.1 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Temsirolimus (Control Group) | Temsirolimus 25 mg intravenously weekly. Upon progression patient crosses over to pazopanib 800 mg orally daily. Treatments stop for progression, toxicity, withdrawal, or death. | 32 | 50 | EG000 |
| Group 2 | Pazopanib (Treatment Group) | Pazopanib 800 mg orally daily. Upon progression patient crosses over to temsirolimus 25 mg intravenously weekly. Treatments stop for progression, toxicity, withdrawal, or death. | 31 | 55 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- Baseline to study completion or date of death from any cause, whichever came first, assessed up to 5 years.
Source ClinicalTrials.gov
Trial
- Title
- Pazopanib Versus Temsirolimus in Poor-Risk Clear-Cell Renal Cell Carcinoma (RCC)
- NCT number
- NCT01392183
- Phases
- PHASE2
- Conditions
- Kidney Cancer
- Interventions
- Pazopanib, Temsirolimus, Quality of Life Assessment, Benadryl
- Lead sponsor
- M.D. Anderson Cancer Center
- Results first posted
- 2021-09-20
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01392183?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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