Comparison · NCT01399723-3bb90bf8
Amoxicillin vs Penicillin: Treatment Failure at or Before Discharge / Day 5 Post Enrollment (Whichever Occurs First)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Amoxicillin vs Penicillin: Treatment Failure at or Before Discharge / Day 5 Post Enrollment (Whichever Occurs First). Trial comparisons, record NCT01399723-3bb90bf8. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01399723-3bb90bf8
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.114 | 0.0811 | 0.158 | wilson | |
| Risk in group 2 | 0.11 | 0.0779 | 0.154 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0038 | -0.0509 | 0.0585 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.03 | 0.64 | 1.67 | log | |
| Odds ratio, group 1 over group 2 | 1.04 | 0.604 | 1.79 | log | |
| Number needed to treat, for one more participant with the outcome on Amoxicillin than on Penicillin | 263 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Amoxicillin | Amoxicillin 45mg/kg 12 hourly | 30 | 263 | OG000 |
| Group 2 | Penicillin | Benzyl Penicillin 50,000IU/kg 6 hourly | 29 | 263 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Treatment Failure at or Before Discharge / Day 5 Post Enrollment (Whichever Occurs First)
- Description
- Treatment failure as defined in the primary outcome measure.
- Time frame
- Patients will be followed up from the day of hospitalisation (day 0) until the day of medical discharge (average duration of 3 days) or until day 5 of hospitalisation (whichever occurs first).
- Population
- Intention to treat analysis
Source ClinicalTrials.gov
Trial
- Title
- Amoxicillin Versus Benzyl Penicillin for Treatment of Children Hospitalised With Severe Pneumonia
- NCT number
- NCT01399723
- Phases
- PHASE3
- Conditions
- Pneumonia
- Interventions
- Amoxicillin, Benzyl penicillin
- Lead sponsor
- KEMRI-Wellcome Trust Collaborative Research Program
- Results first posted
- 2015-02-13
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01399723?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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