Comparison · NCT01468909-a0730ab3
Paclitaxel + Placebo vs Paclitaxel + Pazopanib: Adverse Events as Assessed by CTCAE v.4
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Paclitaxel + Placebo vs Paclitaxel + Pazopanib: Adverse Events as Assessed by CTCAE v.4. Trial comparisons, record NCT01468909-a0730ab3. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01468909-a0730ab3
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.36 | 0.241 | 0.499 | wilson | |
| Risk in group 2 | 0.865 | 0.747 | 0.933 | wilson | |
| Risk difference, group 1 minus group 2 | -0.505 | -0.642 | -0.323 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.416 | 0.283 | 0.611 | log | |
| Odds ratio, group 1 over group 2 | 0.0875 | 0.0327 | 0.234 | log | |
| Number needed to treat, for one fewer participant with the outcome on Paclitaxel + Placebo than on Paclitaxel + Pazopanib | 1.98 | 1.56 | 3.09 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Paclitaxel + Placebo | Paclitaxel 80 mg/m2 administered weekly on days 1, 8 and 15 with Placebo PO daily | 18 | 50 | OG000 |
| Group 2 | Paclitaxel + Pazopanib | Paclitaxel 80 mg/m2 administered weekly on days 1, 8 and 15 with Pazopanib 800 mg PO daily | 45 | 52 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Adverse Events as Assessed by CTCAE v.4
- Description
- All grade 3 or greater Adverse Events (AEs) occurring during treatment and up to 30 days after stopping the study treatment are reported.
- Time frame
- From baseline to 30 days after last dose of drug.
- Population
- Treated and eligible patients
Source ClinicalTrials.gov
Trial
- Title
- Paclitaxel With or Without Pazopanib Hydrochloride in Treating Patients With Persistent or Recurrent Ovarian Epithelial, Fallopian Tube, or Peritoneal Cavity Cancer
- NCT number
- NCT01468909
- Phases
- PHASE2
- Conditions
- Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma
- Interventions
- Laboratory Biomarker Analysis, Paclitaxel, Pazopanib Hydrochloride, Placebo
- Lead sponsor
- National Cancer Institute (NCI)
- Results first posted
- 2019-04-16
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01468909?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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