Chronic HF Without SDB vs Chronic HF With SDB: Nocturnal Dyspnea

Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.

Measures 6

Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.

Measure	Value	95% interval, lower	95% interval, upper	Method	Source
Risk in group 1	0.182	0.17	0.195	wilson	ClinicalTrials.gov
Risk in group 2	0.251	0.236	0.266	wilson	ClinicalTrials.gov
Risk difference, group 1 minus group 2	-0.0685	-0.088	-0.049	newcombe hybrid score	ClinicalTrials.gov
Risk ratio, group 1 over group 2	0.727	0.664	0.796	log	ClinicalTrials.gov
Odds ratio, group 1 over group 2	0.666	0.593	0.748	log	ClinicalTrials.gov
Number needed to treat, for one fewer participant with the outcome on Chronic HF Without SDB than on Chronic HF With SDB	14.6	11.4	20.4	from the risk difference interval	ClinicalTrials.gov

Groups 2

Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.

Group	Title	Description	With the outcome	Analysed	ClinicalTrials.gov code	Source
Group 1	Chronic HF Without SDB	Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and no sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15)	672	3,686	OG000	ClinicalTrials.gov
Group 2	Chronic HF With SDB	Patients with chronic heart failure (left ventricular ejection fraction ≤45% or New York Heart Association (NYHA) class III or IV or NYHA class II with ≥1 hospitalization within 12 months before inclusion) and sleep disordered breathing (SDB, Apnoea-Hypopnoea Index AHI ≥15)	800	3,190	OG001	ClinicalTrials.gov

Outcome 5

Field	Value	Source
Type	SECONDARY	ClinicalTrials.gov
Title	Nocturnal Dyspnea	ClinicalTrials.gov
Description		ClinicalTrials.gov
Time frame	1-time: At baseline history of nocturnal dyspnea taken retrospectively from the medical records	ClinicalTrials.gov
Population		ClinicalTrials.gov

Trial 8

Field	Value	Source
Title	Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry	ClinicalTrials.gov
NCT number	NCT01500759	ClinicalTrials.gov
Phases		ClinicalTrials.gov
Conditions	Congestive Heart Failure, Left Ventricular Systolic Dysfunction	ClinicalTrials.gov
Interventions		ClinicalTrials.gov
Lead sponsor	ResMed	ClinicalTrials.gov
Results first posted	2020-07-09	ClinicalTrials.gov
Results on ClinicalTrials.gov	https://clinicaltrials.gov/study/NCT01500759?tab=results	ClinicalTrials.gov

Source 4

Field	Value	Source
Release	trial-comparisons-2026-03-23-0.1.0	ClinicalTrials.gov
Release manifest SHA-256	f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57	ClinicalTrials.gov
AACT copy	2026-03-23	ClinicalTrials.gov
Tables read	outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet	ClinicalTrials.gov

The same record as JSON

Release trial-comparisons-2026-03-23-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.