Comparison · NCT01526889-8bbc14c6
LFG316 vs Conventional Therapy: Number of Participants With Remission in Study Eye - Treatment Period
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. LFG316 vs Conventional Therapy: Number of Participants With Remission in Study Eye - Treatment Period. Trial comparisons, record NCT01526889-8bbc14c6. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01526889-8bbc14c6
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.111 | 0.031 | 0.328 | wilson | |
| Risk in group 2 | 0 | 0.0000000000000000555 | 0.354 | wilson | |
| Risk difference, group 1 minus group 2 | 0.111 | -0.252 | 0.328 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat, for one more participant with the outcome on LFG316 than on Conventional Therapy | 9 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | LFG316 | LFG316 administered intravitreally | 2 | 18 | OG000 |
| Group 2 | Conventional Therapy | Conventional treatment was selected by the investigator | 0 | 7 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants With Remission in Study Eye - Treatment Period
- Description
Remission (complete response) was defined as any patient who had:~* a vitreous haze score of 0 or 0.5 (scale of 0 to 4) in the study eye, AND~* an anterior chamber cell score of 0 (scale of 0 to 4), AND~* no chorioretinal lesions in the study eye, AND~* was off all immune modulatory therapy (systemic, corticosteroids and topical), AND~* without any worsening of uveitis during the trial.
- Time frame
- Day 85 (end of study)
- Population
- Efficacy 1 analysis set
Source ClinicalTrials.gov
Trial
- Title
- Safety,Tolerability and Efficacy of Intravitreal LFG316 in Patients With Active Non-infectious Intermediate-, posterior-or Panuveitis ,
- NCT number
- NCT01526889
- Phases
- PHASE2
- Conditions
- Non-infectious Intermediate Uveitis, Non-infectious Posterior Uveitis, Non-infectious Panuveitis
- Interventions
- LFG316, Conventional Therapy
- Lead sponsor
- Novartis Pharmaceuticals
- Results first posted
- 2018-10-31
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01526889?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT01526889-8bbc14c6