Comparison · NCT01539226-c49485d4
Dapivirine Vaginal Ring vs Placebo Vaginal Ring: HIV-1 Seroconversion According to Comprehensive HIV Testing Algorithm.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Dapivirine Vaginal Ring vs Placebo Vaginal Ring: HIV-1 Seroconversion According to Comprehensive HIV Testing Algorithm. Trial comparisons, record NCT01539226-c49485d4. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01539226-c49485d4
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.063 | 0.051 | 0.0775 | wilson | |
| Risk in group 2 | 0.0938 | 0.0738 | 0.119 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0309 | -0.0585 | -0.00607 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.671 | 0.488 | 0.922 | log | |
| Odds ratio, group 1 over group 2 | 0.649 | 0.459 | 0.917 | log | |
| Number needed to treat, for one fewer participant with the outcome on Dapivirine Vaginal Ring than on Placebo Vaginal Ring | 32.4 | 17.1 | 165 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Dapivirine Vaginal Ring | Vaginal Ring containing 25mg of Dapivirine~Dapivirine Vaginal Ring, 25 mg: Dapivirine Vaginal Ring containing 25 mg of dapivirine | 82 | 1,302 | OG000 |
| Group 2 | Placebo Vaginal Ring | Vaginal Ring containing 0.0 mg Dapivirine~Placebo Vaginal Ring: Dapivirine Vaginal Ring containing 0.0 mg of dapivirine | 61 | 650 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- HIV-1 Seroconversion According to Comprehensive HIV Testing Algorithm.
- Description
- HIV-1 seroconversion measured by rapid and specialised laboratory testing according to the comprehensive HIV testing algorithm.
- Time frame
- 24 months
- Population
This population consisted of all participants included in the ITT population (all randomised), excluding those who were not identified as HIV-seropositive at the Enrollment Visit, but who were later found to be already HIV-1 infected at enrollment through HIV-1 RNA PCR testing.
Source ClinicalTrials.gov
Trial
- Title
- Safety and Efficacy Trial of a Dapivirine Vaginal Matrix Ring in Healthy HIV-Negative Women
- NCT number
- NCT01539226
- Phases
- NA
- Conditions
- HIV Infections
- Interventions
- Placebo Vaginal Ring, Dapivirine Vaginal Ring, 25 mg
- Lead sponsor
- International Partnership for Microbicides, Inc.
- Results first posted
- 2022-10-19
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01539226?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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