Comparison · NCT01650805-003dc725
Ponatinib vs Imatinib: <10% BCR-ABL^IS Rate
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Ponatinib vs Imatinib: <10% BCR-ABL^IS Rate. Trial comparisons, record NCT01650805-003dc725. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01650805-003dc725
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.945 | 0.885 | 0.975 | wilson | |
| Risk in group 2 | 0.675 | 0.585 | 0.754 | wilson | |
| Risk difference, group 1 minus group 2 | 0.27 | 0.17 | 0.365 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.4 | 1.22 | 1.6 | log | |
| Odds ratio, group 1 over group 2 | 8.25 | 3.31 | 20.5 | log | |
| Number needed to treat, for one more participant with the outcome on Ponatinib than on Imatinib | 3.71 | 2.74 | 5.87 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Ponatinib | ponatinib: 45 mg tablet, taken orally once daily | 103 | 109 | OG000 |
| Group 2 | Imatinib | imatinib (Gleevec/ Glivec): 400 mg tablet, taken orally once daily | 77 | 114 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- <10% BCR-ABL^IS Rate
- Description
To compare the proportion of patients achieving a ratio of \<10% BCR-ABL to ABL transcript levels at 3 months, as measured by the international scale (\<10% BCR-ABL\^IS), in patients administered ponatinib versus those administered imatinib
- Time frame
- 3 months after first dose
- Population
- Patients with 3 month assessment
Source ClinicalTrials.gov
Trial
- Title
- Ponatinib in Newly Diagnosed Chronic Myeloid Leukemia (CML) (EPIC)
- NCT number
- NCT01650805
- Phases
- PHASE3
- Conditions
- Chronic Myeloid Leukemia
- Interventions
- ponatinib, imatinib (Gleevec/ Glivec)
- Lead sponsor
- Ariad Pharmaceuticals
- Results first posted
- 2014-10-21
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01650805?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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