Comparison · NCT01650805-17246cb2
Ponatinib vs Imatinib: Complete Cytogenetic Response (CCyR) Rate
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Ponatinib vs Imatinib: Complete Cytogenetic Response (CCyR) Rate. Trial comparisons, record NCT01650805-17246cb2. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01650805-17246cb2
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 1 | 0.566 | 1 | wilson | |
| Risk in group 2 | 0.857 | 0.487 | 0.974 | wilson | |
| Risk difference, group 1 minus group 2 | 0.143 | -0.307 | 0.513 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.17 | 0.862 | 1.58 | log | |
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat, for one more participant with the outcome on Ponatinib than on Imatinib | 7 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Ponatinib | ponatinib: 45 mg tablet, taken orally once daily | 5 | 5 | OG000 |
| Group 2 | Imatinib | imatinib (Gleevec/ Glivec): 400 mg tablet, taken orally once daily | 6 | 7 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Complete Cytogenetic Response (CCyR) Rate
- Description
- The percentage of Ph+ metaphases in bone marrow (peripheral blood may not be used), with a review of a minimum of 20 metaphases. Responses are defined as follows: Complete (CCyR): 0% Ph+ metaphases.
- Time frame
- 12 months after first dose
- Population
- Patients with 12 month assessment
Source ClinicalTrials.gov
Trial
- Title
- Ponatinib in Newly Diagnosed Chronic Myeloid Leukemia (CML) (EPIC)
- NCT number
- NCT01650805
- Phases
- PHASE3
- Conditions
- Chronic Myeloid Leukemia
- Interventions
- ponatinib, imatinib (Gleevec/ Glivec)
- Lead sponsor
- Ariad Pharmaceuticals
- Results first posted
- 2014-10-21
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01650805?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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