Comparison · NCT01669811-sae
D961H 20 mg BID vs D961H 20 mg QD + Placebo: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. D961H 20 mg BID vs D961H 20 mg QD + Placebo: serious adverse events. Trial comparisons, record NCT01669811-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01669811-sae
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0069 | 0.00122 | 0.038 | wilson | |
| Risk in group 2 | 0.0211 | 0.00721 | 0.0603 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0142 | -0.0538 | 0.0199 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.326 | 0.0344 | 3.1 | log | |
| Odds ratio, group 1 over group 2 | 0.322 | 0.0331 | 3.13 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on D961H 20 mg BID than on D961H 20 mg QD + Placebo | 70.3 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | D961H 20 mg BID | D961H 20 mg twice Daily | 1 | 145 | EG000 |
| Group 2 | D961H 20 mg QD + Placebo | D961H 20 mg once daily along with placebo | 3 | 142 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
Source ClinicalTrials.gov
Trial
- Title
- Compare D961H 20 mg Bid and 20 mg qd in Patients With Refractory Reflux Esophagitis (Inflammation of Lower Esophagus)
- NCT number
- NCT01669811
- Phases
- PHASE3
- Conditions
- Refractory Reflux Esophagitis
- Interventions
- Esomeprazole (D961H) twice daily, Esomeprazole (D961H) once daily
- Lead sponsor
- AstraZeneca
- Results first posted
- 2015-08-14
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01669811?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT01669811-sae