Comparison · NCT01680887-5dcf02ae
Varenicline vs Placebo: Number of Participants Who Report no Cocaine Use and Have no Cocaine Positive Urine Drug Screens in the Chantix Group Versus the Placebo Group Comparator During the Last Three Weeks of the Trial
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Varenicline vs Placebo: Number of Participants Who Report no Cocaine Use and Have no Cocaine Positive Urine Drug Screens in the Chantix Group Versus the Placebo Group Comparator During the Last Three Weeks of the Trial. Trial comparisons, record NCT01680887-5dcf02ae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01680887-5dcf02ae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.075 | 0.0348 | 0.154 | wilson | |
| Risk in group 2 | 0.0921 | 0.0453 | 0.178 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0171 | -0.112 | 0.0748 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.814 | 0.287 | 2.31 | log | |
| Odds ratio, group 1 over group 2 | 0.799 | 0.256 | 2.5 | log | |
| Number needed to treat, for one fewer participant with the outcome on Varenicline than on Placebo | 58.5 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Varenicline | Oral 1.0 mg BID.~Varenicline | 6 | 80 | OG000 |
| Group 2 | Placebo | Oral 1.0 mg BID.~Placebo | 7 | 76 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants Who Report no Cocaine Use and Have no Cocaine Positive Urine Drug Screens in the Chantix Group Versus the Placebo Group Comparator During the Last Three Weeks of the Trial
- Description
Number of subjects with cocaine abstinence as measured through three-times-weekly urine benzoylecgonine (BE) levels in urine drug screen (UDS) and self-reports of use from the Time Line Follow Back. UDS results and TLFB reports combined to yield weekly use/no-use indicators for each week of treatment.
- Time frame
- weeks 11,12,13 of the trial
- Population
- all subject
Source ClinicalTrials.gov
Trial
- Title
- A Phase II Trial of Varenicline for the Treatment of Cocaine Dependence
- NCT number
- NCT01680887
- Phases
- PHASE2
- Conditions
- Cocaine Dependence
- Interventions
- Varenicline, Placebo
- Lead sponsor
- University of Pennsylvania
- Results first posted
- 2019-08-06
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01680887?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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