Comparison · NCT01696084-66bdbefd
Arm A (CPX-351) vs Arm B (7+3): Proportion of Subjects With a Response
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Arm A (CPX-351) vs Arm B (7+3): Proportion of Subjects With a Response. Trial comparisons, record NCT01696084-66bdbefd. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01696084-66bdbefd
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.373 | 0.3 | 0.451 | wilson | |
| Risk in group 2 | 0.256 | 0.194 | 0.33 | wilson | |
| Risk difference, group 1 minus group 2 | 0.116 | 0.0126 | 0.217 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.45 | 1.04 | 2.04 | log | |
| Odds ratio, group 1 over group 2 | 1.72 | 1.06 | 2.8 | log | |
| Number needed to treat, for one more participant with the outcome on Arm A (CPX-351) than on Arm B (7+3) | 8.61 | 4.62 | 79.3 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Arm A (CPX-351) | Subjects are eligible to receive up to 2 inductions and up to 2 consolidations with CPX-351. The number of inductions and consolidations a subject received depended on response. | 57 | 153 | OG000 |
| Group 2 | Arm B (7+3) | Subjects are eligible to receive up to 2 inductions and up to 2 consolidations with cytarabine and daunorubicin given as a 7 + 3, or 5 days of continuous infusion of cytarabine and 2 days of daunorubicin (5+2, second induction, consolidation courses) therapy. The number of inductions and consolidations a subject received depended on response. | 40 | 156 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Proportion of Subjects With a Response
- Description
- Complete Remission (CR)
- Time frame
- Post Induction
- Population
- Intent-to-Treat (ITT) Population: All participants randomized in the study.
Source ClinicalTrials.gov
Trial
- Title
- Phase III Study of CPX-351 Versus 7+3 in Patients 60-75 Years Old With Untreated High Risk (Secondary) Acute Myeloid Leukemia
- NCT number
- NCT01696084
- Phases
- PHASE3
- Conditions
- High Risk Acute Myeloid Leukemia
- Interventions
- CPX-351, 7+3 (cytarabine and daunorubicin)
- Lead sponsor
- Jazz Pharmaceuticals
- Results first posted
- 2017-10-02
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01696084?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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