Colorectal Screening vs Control: Colorectal Cancer Incidence

Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.

Measures 6

Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.

Measure	Value	95% interval, lower	95% interval, upper	Method	Source
Risk in group 1	0.0131	0.0123	0.0139	wilson	ClinicalTrials.gov
Risk in group 2	0.0166	0.0157	0.0175	wilson	ClinicalTrials.gov
Risk difference, group 1 minus group 2	-0.00355	-0.00476	-0.00235	newcombe hybrid score	ClinicalTrials.gov
Risk ratio, group 1 over group 2	0.786	0.725	0.853	log	ClinicalTrials.gov
Odds ratio, group 1 over group 2	0.784	0.721	0.851	log	ClinicalTrials.gov
Number needed to treat, for one fewer participant with the outcome on Colorectal Screening than on Control	282	210	426	from the risk difference interval	ClinicalTrials.gov

Groups 2

Group 2 names the comparator: control.

Group	Title	Description	With the outcome	Analysed	ClinicalTrials.gov code	Source
Group 1	Colorectal Screening	Participants undergo a colorectal examination with a flexible sigmoidoscope at baseline and year 5. Participants complete a Dietary Questionnaire (DQX) at baseline and a Dietary History Questionnaire (DHQ) at study years 3-6. An Annual Study Update (ASU) (previously referred to as the Periodic Survey of Health \[PSH\] questionnaire) is mailed to each participant annually for 13 years to identify all prevalent and incident colorectal cancers and all deaths that occur among both screened and control arm subjects during the trial.	1,012	77,445	OG001	ClinicalTrials.gov
Group 2	Control	Participants receive standard medical care. Participants complete a baseline questionnaire at entry and a dietary history questionnaire (DHQ) during study years 0-6.	1,287	77,455	OG000	ClinicalTrials.gov

Outcome 5

Field	Value	Source
Type	SECONDARY	ClinicalTrials.gov
Title	Colorectal Cancer Incidence	ClinicalTrials.gov
Description	Colorectal cancer diagnoses confirmed by medical record abstraction.	ClinicalTrials.gov
Time frame	Events through 13 years of follow-up or through December 31, 2009; median follow-up 12.1 years.	ClinicalTrials.gov
Population	All participants. An intention-to-treat analysis was performed.	ClinicalTrials.gov

Trial 8

Field	Value	Source
Title	Screening for Colorectal Cancer in Older Patients (PLCO Screening Trial)	ClinicalTrials.gov
NCT number	NCT01696981	ClinicalTrials.gov
Phases	NA	ClinicalTrials.gov
Conditions	Colon Carcinoma, Rectal Carcinoma	ClinicalTrials.gov
Interventions	Screening Questionnaire Administration, Sigmoidoscopy	ClinicalTrials.gov
Lead sponsor	National Cancer Institute (NCI)	ClinicalTrials.gov
Results first posted	2014-07-21	ClinicalTrials.gov
Results on ClinicalTrials.gov	https://clinicaltrials.gov/study/NCT01696981?tab=results	ClinicalTrials.gov

Source 4

Field	Value	Source
Release	trial-comparisons-2026-03-23-0.1.0	ClinicalTrials.gov
Release manifest SHA-256	f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57	ClinicalTrials.gov
AACT copy	2026-03-23	ClinicalTrials.gov
Tables read	outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet	ClinicalTrials.gov

The same record as JSON

Release trial-comparisons-2026-03-23-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.