Colorectal Screening vs Control: Deaths From All Causes
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.14 | 0.137 | 0.142 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.143 | 0.14 | 0.145 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | -0.00294 | -0.00641 | 0.000532 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 0.979 | 0.956 | 1 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 0.976 | 0.949 | 1 | log | ClinicalTrials.gov | |
| Number needed to treat, for one fewer participant with the outcome on Colorectal Screening than on Control | 340 | from the risk difference interval | the interval includes no difference | ClinicalTrials.gov |
Groups 2
Group 2 names the comparator: control.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | Colorectal Screening | Participants undergo a colorectal examination with a flexible sigmoidoscope at baseline and year 5. Participants complete a Dietary Questionnaire (DQX) at baseline and a Dietary History Questionnaire (DHQ) at study years 3-6. An Annual Study Update (ASU) (previously referred to as the Periodic Survey of Health \[PSH\] questionnaire) is mailed to each participant annually for 13 years to identify all prevalent and incident colorectal cancers and all deaths that occur among both screened and control arm subjects during the trial. | 10,835 | 77,445 | OG001 | ClinicalTrials.gov |
| Group 2 | Control | Participants receive standard medical care. Participants complete a baseline questionnaire at entry and a dietary history questionnaire (DHQ) during study years 0-6. | 11,064 | 77,455 | OG000 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | SECONDARY | ClinicalTrials.gov |
| Title | Deaths From All Causes | ClinicalTrials.gov |
| Description | Deaths from all causes were compared between the colorectal cancer screening arm and the usual care arm. | ClinicalTrials.gov |
| Time frame | Events through 13 years of follow-up or through December 31, 2009; median follow-up 12.1 years. | ClinicalTrials.gov |
| Population | All participants. An intention-to-treat analysis was performed. | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | Screening for Colorectal Cancer in Older Patients (PLCO Screening Trial) | ClinicalTrials.gov |
| NCT number | NCT01696981 | ClinicalTrials.gov |
| Phases | NA | ClinicalTrials.gov |
| Conditions | Colon Carcinoma, Rectal Carcinoma | ClinicalTrials.gov |
| Interventions | Screening Questionnaire Administration, Sigmoidoscopy | ClinicalTrials.gov |
| Lead sponsor | National Cancer Institute (NCI) | ClinicalTrials.gov |
| Results first posted | 2014-07-21 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT01696981?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.