Comparison · NCT01709409-001ceb68
Curosurf (Group 1) vs BLES (Group 2): The Primary Objective of the Study is to Compare Between the Two Groups, the Number of Subjects Alive and Extubated at 48 Hours Post Surfactant Administration. Extubation
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Curosurf (Group 1) vs BLES (Group 2): The Primary Objective of the Study is to Compare Between the Two Groups, the Number of Subjects Alive and Extubated at 48 Hours Post Surfactant Administration. Extubation. Trial comparisons, record NCT01709409-001ceb68. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01709409-001ceb68
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.5 | 0.355 | 0.645 | wilson | |
| Risk in group 2 | 0.578 | 0.433 | 0.71 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0778 | -0.274 | 0.127 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.865 | 0.585 | 1.28 | log | |
| Odds ratio, group 1 over group 2 | 0.731 | 0.314 | 1.7 | log | |
| Number needed to treat, for one fewer participant with the outcome on Curosurf (Group 1) than on BLES (Group 2) | 12.9 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Curosurf (Group 1) | Surfactant(Curosurf in this arm) was given for treatment of established RDS. The treatment dose for Curosurf® was 2.5 ml/kg (200mg/kg) for the first dose and 1.25 ml/kg (100mg/kg) for repeat doses, given by endotracheal method. There was a maximum of 3 doses in the study. | 21 | 42 | OG000 |
| Group 2 | BLES (Group 2) | Surfactant(BLES in this arm) was given for treatment of established RDS. The treatment dose for BLES was 5 ml/kg. given by endotracheal method. There was a maximum of 3 doses in the study. | 26 | 45 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- The Primary Objective of the Study is to Compare Between the Two Groups, the Number of Subjects Alive and Extubated at 48 Hours Post Surfactant Administration. Extubation
- Description
- 1. rate on ventilator ≤40 per minute and~2. mean airway pressure ≤ 10 cm H20 and~3. fi02 ≤ 30%
- Time frame
- 48 hours
- Population
Source ClinicalTrials.gov
Trial
- Title
- A Multi-center Trial to Determine if Curosurf® Reduces the Duration of Mechanical Ventilation in Very Preterm Infants
- NCT number
- NCT01709409
- Phases
- PHASE3
- Conditions
- Respiratory Distress Syndrome
- Interventions
- Curosurf-Group1, BLES-group 2
- Lead sponsor
- Ottawa Hospital Research Institute
- Results first posted
- 2017-10-25
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01709409?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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