Comparison · NCT01720667-8370d3dd
Intravenous Levetiracetam vs Intravenous Phenobarbital: Neonates With Seizure Cessation When Given Levetiracetam as First Line Therapy Compared to Phenobarbital Within the Hypoxic Ischemic Encephalopathy (HIE) Population and Treated With Hypothermia
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Intravenous Levetiracetam vs Intravenous Phenobarbital: Neonates With Seizure Cessation When Given Levetiracetam as First Line Therapy Compared to Phenobarbital Within the Hypoxic Ischemic Encephalopathy (HIE) Population and Treated With Hypothermia. Trial comparisons, record NCT01720667-8370d3dd. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01720667-8370d3dd
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.353 | 0.173 | 0.587 | wilson | |
| Risk in group 2 | 0.9 | 0.596 | 0.982 | wilson | |
| Risk difference, group 1 minus group 2 | -0.547 | -0.745 | -0.163 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.392 | 0.199 | 0.771 | log | |
| Odds ratio, group 1 over group 2 | 0.0606 | 0.00612 | 0.6 | log | |
| Number needed to treat, for one fewer participant with the outcome on Intravenous Levetiracetam than on Intravenous Phenobarbital | 1.83 | 1.34 | 6.12 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Intravenous Levetiracetam | Intravenous levetiracetam 40 - 60 mg/kg loading dose \& 10 mg/kg 8 hourly maintenance | 6 | 17 | OG000 |
| Group 2 | Intravenous Phenobarbital | Intravenous phenobarbital 20 - 40 mg/kg loading dose \& 1.5 mg/kg 8 hourly maintenance. | 9 | 10 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Neonates With Seizure Cessation When Given Levetiracetam as First Line Therapy Compared to Phenobarbital Within the Hypoxic Ischemic Encephalopathy (HIE) Population and Treated With Hypothermia
- Description
- Time frame
- 24 hours
- Population
- HIE participants with hypothermia treatment
Source ClinicalTrials.gov
Trial
- Title
- Efficacy of Intravenous Levetiracetam in Neonatal Seizures
- NCT number
- NCT01720667
- Phases
- PHASE1, PHASE2
- Conditions
- Neonatal Seizures
- Interventions
- Intravenous levetiracetam, Intravenous phenobarbital
- Lead sponsor
- Richard H. Haas
- Results first posted
- 2019-08-21
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01720667?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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