Comparison · NCT01720667-ea1d68ff
Intravenous Levetiracetam vs Intravenous Phenobarbital: LEV Dose Escalation Component
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Intravenous Levetiracetam vs Intravenous Phenobarbital: LEV Dose Escalation Component. Trial comparisons, record NCT01720667-ea1d68ff. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01720667-ea1d68ff
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0755 | 0.0297 | 0.179 | wilson | |
| Risk in group 2 | 0.1 | 0.0346 | 0.256 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0245 | -0.187 | 0.0976 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.755 | 0.181 | 3.15 | log | |
| Odds ratio, group 1 over group 2 | 0.735 | 0.153 | 3.53 | log | |
| Number needed to treat, for one fewer participant with the outcome on Intravenous Levetiracetam than on Intravenous Phenobarbital | 40.8 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Intravenous Levetiracetam | Intravenous levetiracetam 40 mg/kg loading dose \& 10 mg/kg 8 hourly maintenance | 4 | 53 | OG000 |
| Group 2 | Intravenous Phenobarbital | Intravenous phenobarbital 20 mg/kg loading dose \& 1.5 mg/kg 8 hourly maintenance. | 3 | 30 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- LEV Dose Escalation Component
- Description
- Number of babies with seizure control at levetiracetam (60 mg/Kg load) who had not responded to 40 mg/kg load and number of babies with seizure control at 40 mg/kg who had not responded to 20 mg/kg.
- Time frame
- 24 hours
- Population
- Babies who received any treatment of either phenobarbital or levetiracetam within the modified intent to treat
Source ClinicalTrials.gov
Trial
- Title
- Efficacy of Intravenous Levetiracetam in Neonatal Seizures
- NCT number
- NCT01720667
- Phases
- PHASE1, PHASE2
- Conditions
- Neonatal Seizures
- Interventions
- Intravenous levetiracetam, Intravenous phenobarbital
- Lead sponsor
- Richard H. Haas
- Results first posted
- 2019-08-21
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01720667?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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