Comparison · NCT01742117-deaths
Genotype-Guided Therapy vs Conventional Therapy: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Genotype-Guided Therapy vs Conventional Therapy: deaths from any cause. Trial comparisons, record NCT01742117-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01742117-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.036 | 0.0295 | 0.0438 | wilson | |
| Risk in group 2 | 0.0372 | 0.0306 | 0.0451 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00122 | -0.0114 | 0.00898 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.967 | 0.733 | 1.28 | log | |
| Odds ratio, group 1 over group 2 | 0.966 | 0.725 | 1.29 | log | |
| Number needed to treat, for one fewer death from any cause on Genotype-Guided Therapy than on Conventional Therapy | 819 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Genotype-Guided Therapy | Subjects will be genotyped prospectively for CYP2C19\*2, \*3 and \*17 alleles and will receive treatment based on their genotype. In this group, patients who have the CYP2C19 reduced function allele \[i.e., \*2 allele (heterozygous or homozygous) or \*3 allele (heterozygous or homozygous)\] patients will receive ticagrelor 90 mg bid. The WT YP2C19 patients will receive clopidogrel 75 mg once daily.~Clopidogrel: One 75 mg tablet per day by mouth for one year~Ticagrelor: One 90 mg tablet twice per day by mouth for one year | 95 | 2,641 | EG000 |
| Group 2 | Conventional Therapy | Subjects will receive clopidogrel once daily after the index PCI and will be retrospectively genotyped for CYP2C19\*2, \*3 and \*17 alleles after completion of one year of treatment with clopidogrel.~Clopidogrel: One 75 mg tablet per day by mouth for one year | 98 | 2,635 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
Source ClinicalTrials.gov
Trial
- Title
- Tailored Antiplatelet Therapy Following PCI
- NCT number
- NCT01742117
- Phases
- PHASE4
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Stenosis
- Interventions
- Clopidogrel, Ticagrelor
- Lead sponsor
- Mayo Clinic
- Results first posted
- 2021-11-09
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01742117?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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