Comparison · NCT01756846-sae
HEART Care vs Usual Care: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. HEART Care vs Usual Care: serious adverse events. Trial comparisons, record NCT01756846-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01756846-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.189 | 0.172 | 0.208 | wilson | |
| Risk in group 2 | 0.222 | 0.203 | 0.241 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0322 | -0.0584 | -0.00599 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.855 | 0.752 | 0.971 | log | |
| Odds ratio, group 1 over group 2 | 0.821 | 0.699 | 0.964 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on HEART Care than on Usual Care | 31 | 17.1 | 167 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: usual care.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | HEART Care | HEART care: usual care, complemented by calculation of the HEART score and following the recommended policy.~During 14 months, patients presenting with chest pain to the ED of participating hospitals were included in the study. First, all hospitals applied 'usual care' to all patients, i.e. risk assessment and subsequent management without application of the HEART score. Then, during a 14 month period, each 1,5 month 1 randomly allocated hospital sequentially started to apply the HEART score in all chest pain patients (intervention period); during this intervention period patients with a HEART score 0-3 were advised not be admitted to the hospital, and patients with a HEART score above 3 were advised to be treated according to current guidelines. | 345 | 1,821 | EG001 |
| Group 2 | Usual Care | usual care was defined as daily practice of the cardiologist or attending emergency doctor, in order to diagnose a patient with chest pain. In this period attending doctors assess the risk of a patient with chest pain, based on his/hers experience and various criteria (for example described in European Society of Cardiology Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation, without a formal risk score). | 405 | 1,827 | EG000 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- 6 weeks
Source ClinicalTrials.gov
Trial
- Title
- Impact on Management of the HEART Risk Score in Chest Pain Patients
- NCT number
- NCT01756846
- Phases
- NA
- Conditions
- Chest Pain
- Interventions
- usual care, use of HEART risk score
- Lead sponsor
- UMC Utrecht
- Results first posted
- 2019-01-25
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01756846?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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