Comparison · NCT01780935-sae
RBZ 0.5 mg: VA Only (Group I) vs RBZ 0.5 mg: VA and/or OCT (Group II): serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. RBZ 0.5 mg: VA Only (Group I) vs RBZ 0.5 mg: VA and/or OCT (Group II): serious adverse events. Trial comparisons, record NCT01780935-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01780935-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0898 | 0.0636 | 0.125 | wilson | |
| Risk in group 2 | 0.134 | 0.102 | 0.175 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0441 | -0.0924 | 0.0039 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.671 | 0.433 | 1.04 | log | |
| Odds ratio, group 1 over group 2 | 0.638 | 0.391 | 1.04 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on RBZ 0.5 mg: VA Only (Group I) than on RBZ 0.5 mg: VA and/or OCT (Group II) | 22.7 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | RBZ 0.5 mg: VA Only (Group I) | RBZ 0.5 mg: Visual Acuity (VA) only (Group I) 0.5 mg intravitreal injections of ranibizumab with retreatment based on best-corrected visual acuity (BCVA) loss due to neovascular (wet) age-related macular degeneration (nAMD) | 30 | 334 | EG000 |
| Group 2 | RBZ 0.5 mg: VA and/or OCT (Group II) | RBZ 0.5 mg: VA and/or OCT (Group II) 0.5 mg intravitreal injections of ranibizumab with retreatment based on best-corrected visual acuity (BCVA)loss due to neovascular (wet) age-related macular degeneration (nAMD) and/or signs of wet AMD disease activity on optical coherence tomography (OCT). | 45 | 336 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
Source ClinicalTrials.gov
Trial
- Title
Efficacy and Safety of Two Treatment Regimens of 0.5 mg Ranibizumab Intravitreal Injections Guided by Functional and/or Anatomical Criteria, in Patients With Neovascular Age-related Macular Degeneration
- NCT number
- NCT01780935
- Phases
- PHASE3
- Conditions
- Neovascular Age-related Macular Degeneration
- Interventions
- Ranibizumab
- Lead sponsor
- Novartis Pharmaceuticals
- Results first posted
- 2017-01-02
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01780935?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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