Comparison · NCT01814332-331b5646
GSK561679 vs Placebo: Efficacy, Measured by Response Rate of at Least 50% Improvement in CAPS Score at the End of 6 Weeks as Compared to Baseline
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. GSK561679 vs Placebo: Efficacy, Measured by Response Rate of at Least 50% Improvement in CAPS Score at the End of 6 Weeks as Compared to Baseline. Trial comparisons, record NCT01814332-331b5646. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01814332-331b5646
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.222 | 0.137 | 0.339 | wilson | |
| Risk in group 2 | 0.277 | 0.183 | 0.396 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0547 | -0.201 | 0.0953 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.802 | 0.438 | 1.47 | log | |
| Odds ratio, group 1 over group 2 | 0.746 | 0.334 | 1.67 | log | |
| Number needed to treat, for one fewer participant with the outcome on GSK561679 than on Placebo | 18.3 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | GSK561679 | GSK561679, oral administration, 350mg/day, 6 week administration~GSK561679: GSK561679, oral administration, 350mg/day, 6 week administration | 14 | 63 | OG000 |
| Group 2 | Placebo | Placebo compound treatment for comparison with IP~Placebo: Placebo compound treatment for comparison with IP | 18 | 65 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Efficacy, Measured by Response Rate of at Least 50% Improvement in CAPS Score at the End of 6 Weeks as Compared to Baseline
- Description
The number of participants that showed at least a 50% reduction in CAPS scores from their baseline visit at the end of 6 weeks were measured as having a response to the treatment. The CAPS is a semi-structured clinical interview providing a measure of the severity of PTSD symptoms. A severity score is calculated by summing the frequency and intensity scores for each of the 17 DSM-IV criteria symptoms. Scores may range from 0 (no symptoms) to 136 (severe symptoms).
- Time frame
- Baseline, Week 6
- Population
Source ClinicalTrials.gov
Trial
- Title
- Analyzing Female Trauma Exposed Responses to a Medication
- NCT number
- NCT01814332
- Phases
- PHASE2
- Conditions
- Stress Disorders, Post-traumatic
- Interventions
- GSK561679, Placebo
- Lead sponsor
- VA Office of Research and Development
- Results first posted
- 2016-04-25
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01814332?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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