Comparison · NCT01821118-cfb57ef8
PF-04360365 vs Placebo: Number of Participants With Laboratory Abnormalities
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. PF-04360365 vs Placebo: Number of Participants With Laboratory Abnormalities. Trial comparisons, record NCT01821118-cfb57ef8. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01821118-cfb57ef8
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.583 | 0.388 | 0.755 | wilson | |
| Risk in group 2 | 0.833 | 0.552 | 0.953 | wilson | |
| Risk difference, group 1 minus group 2 | -0.25 | -0.479 | 0.0798 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.7 | 0.459 | 1.07 | log | |
| Odds ratio, group 1 over group 2 | 0.28 | 0.0501 | 1.57 | log | |
| Number needed to treat, for one fewer participant with the outcome on PF-04360365 than on Placebo | 4 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | PF-04360365 | Participants received a loading dose of PF-04360365 10 milligrams (mg)/kilograms (kg) on Day 1, followed by PF-04360365 7.5 mg/kg on Days 30 and 60. PF-04360365 was administered via intravenous (IV) infusion over a period of 10-15 minutes (min) and dosing was based on participant weight. | 14 | 24 | OG000 |
| Group 2 | Placebo | Participants received a loading dose of placebo matching PF-04360365 10 mg/kg on Day 1, followed by placebo matching PF-04360365 7.5 mg/kg on Days 30 and 60. Placebo was also administered via IV infusion over a period of 10-15 min. | 10 | 12 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Laboratory Abnormalities
- Description
Number of participants with laboratory test abnormalities without regard to baseline abnormality. Laboratory test parameters included hematology, liver function (including Hy's Law Criteria), renal function, electrolytes, clinical chemistry, and urinalysis (dipstick and microscopy).
- Time frame
- Baseline up to Day 240
- Population
- All 36 participants who received study drug were included in the analysis.
Source ClinicalTrials.gov
Trial
- Title
- Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy
- NCT number
- NCT01821118
- Phases
- PHASE2
- Conditions
- Cerebral Amyloid Angiopathy
- Interventions
- Ponezumab, placebo
- Lead sponsor
- Pfizer
- Results first posted
- 2016-11-03
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01821118?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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