Comparison · NCT01823328-3288b0dd
Ketamine vs Etomidate: Mortality
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Ketamine vs Etomidate: Mortality. Trial comparisons, record NCT01823328-3288b0dd. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01823328-3288b0dd
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.129 | 0.0669 | 0.234 | wilson | |
| Risk in group 2 | 0.224 | 0.141 | 0.337 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0948 | -0.224 | 0.0395 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.576 | 0.263 | 1.26 | log | |
| Odds ratio, group 1 over group 2 | 0.514 | 0.201 | 1.31 | log | |
| Number needed to treat, for one fewer participant with the outcome on Ketamine than on Etomidate | 10.5 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Ketamine | Subjects in the ketamine arm will receive ketamine for sedation prior to rapid sequence intubation (RSI).~Ketamine: Subjects will receive ketamine for sedation prior to rapid sequence intubation. | 8 | 62 | OG000 |
| Group 2 | Etomidate | Subjects in the etomidate arm will receive etomidate for sedation prior to rapid sequence intubation (RSI).~Etomidate: Subjects will receive etomidate for sedation prior to rapid sequence intubation. | 15 | 67 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Mortality
- Description
Mortality will be assessed at 30 days or at discharge from the hospital, whichever occurs first. This study is not powered to detect a significant difference in mortality, however; this will primarily be a safety study comparing the use ketamine versus etomidate as sedative agents for rapid sequence intubation (RSI) in the Emergency Department (ED).
- Time frame
- 30 Days or Discharge
- Population
Source ClinicalTrials.gov
Trial
- Title
- Ketamine Versus Etomidate for Rapid Sequence Intubation
- NCT number
- NCT01823328
- Phases
- PHASE4
- Conditions
- Airway Control, Anesthesia, Intubation, Complication
- Interventions
- Ketamine, Etomidate
- Lead sponsor
- Hennepin Healthcare Research Institute
- Results first posted
- 2019-05-24
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01823328?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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