Comparison · NCT01823328-9ad264aa
Ketamine vs Etomidate: Mortality in Sepsis and Septic Shock
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Ketamine vs Etomidate: Mortality in Sepsis and Septic Shock. Trial comparisons, record NCT01823328-9ad264aa. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01823328-9ad264aa
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.111 | 0.0199 | 0.435 | wilson | |
| Risk in group 2 | 0.25 | 0.102 | 0.495 | wilson | |
| Risk difference, group 1 minus group 2 | -0.139 | -0.4 | 0.217 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.444 | 0.0582 | 3.4 | log | |
| Odds ratio, group 1 over group 2 | 0.375 | 0.0352 | 4 | log | |
| Number needed to treat, for one fewer participant with the outcome on Ketamine than on Etomidate | 7.2 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Ketamine | Subjects in the ketamine arm will receive ketamine for sedation prior to rapid sequence intubation (RSI).~Ketamine: Subjects will receive ketamine for sedation prior to rapid sequence intubation. | 1 | 9 | OG000 |
| Group 2 | Etomidate | Subjects in the etomidate arm will receive etomidate for sedation prior to rapid sequence intubation (RSI).~Etomidate: Subjects will receive etomidate for sedation prior to rapid sequence intubation. | 4 | 16 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Mortality in Sepsis and Septic Shock
- Description
Evaluate mortality for the sub-group diagnosed with sepsis and septic shock, defined as:~\- Suspected infection, and at least 2 of 4 systemic inflammatory response syndrome (SIRS) criteria:~1. Temperature \>38C or \<36C~2. Respiratory Rate \>20 or PaCO2 \<32 mmHg~3. Heart Rate \>90~4. White blood cell count \>12,000 or \<4,000, or \> 10% bands~Septic shock:~defined as sepsis plus either: 1) Systolic blood pressure \<90 after 1L of intravenous fluid or 2) lactate \>=4mmol/L
- Time frame
- 30 Days
- Population
- Subgroup of those with sepsis
Source ClinicalTrials.gov
Trial
- Title
- Ketamine Versus Etomidate for Rapid Sequence Intubation
- NCT number
- NCT01823328
- Phases
- PHASE4
- Conditions
- Airway Control, Anesthesia, Intubation, Complication
- Interventions
- Ketamine, Etomidate
- Lead sponsor
- Hennepin Healthcare Research Institute
- Results first posted
- 2019-05-24
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01823328?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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