Comparison · NCT01838499-sae
MEDI8968 vs Saline: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. MEDI8968 vs Saline: serious adverse events. Trial comparisons, record NCT01838499-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01838499-sae
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0364 | 0.01 | 0.123 | wilson | |
| Risk in group 2 | 0.037 | 0.0102 | 0.125 | wilson | |
| Risk difference, group 1 minus group 2 | -0.000673 | -0.0928 | 0.0902 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.982 | 0.143 | 6.72 | log | |
| Odds ratio, group 1 over group 2 | 0.981 | 0.133 | 7.23 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on MEDI8968 than on Saline | 1,490 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | MEDI8968 | SC injection | 2 | 55 | EG000 |
| Group 2 | Saline | SC injection | 2 | 54 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- 24 weeks. However, if a subject withdraws from treatment for any reason prior to week 24, the subject should continue to be seen up to 16 weeks after his/her last dose.
Source ClinicalTrials.gov
Trial
- Title
- Assessment of the Safety, Tolerability and Efficacy of MEDI8968 in Subjects With Moderate to Severe Hidradenitis Suppurativa
- NCT number
- NCT01838499
- Phases
- PHASE2
- Conditions
- Hidradenitis Suppurativa
- Interventions
- MEDI8968, Saline
- Lead sponsor
- AstraZeneca
- Results first posted
- 2016-09-01
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01838499?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT01838499-sae