Comparison · NCT01865747-sae
Cabozantinib (XL184) vs Everolimus (Afinitor): serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Cabozantinib (XL184) vs Everolimus (Afinitor): serious adverse events. Trial comparisons, record NCT01865747-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01865747-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.396 | 0.345 | 0.449 | wilson | |
| Risk in group 2 | 0.432 | 0.379 | 0.486 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0359 | -0.111 | 0.0394 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.917 | 0.764 | 1.1 | log | |
| Odds ratio, group 1 over group 2 | 0.862 | 0.631 | 1.18 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Cabozantinib (XL184) than on Everolimus (Afinitor) | 27.9 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Cabozantinib (XL184) | Cabozantinib (XL184) 60 mg tablet once daily.~Cabozantinib tablets | 131 | 331 | EG000 |
| Group 2 | Everolimus (Afinitor) | Everolimus (Afinitor) 10 mg tablet once daily.~Everolimus (Afinitor) tablets | 139 | 322 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- 08 August 2013 - 22 May 2015
Source ClinicalTrials.gov
Trial
- Title
- A Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma
- NCT number
- NCT01865747
- Phases
- PHASE3
- Conditions
- Renal Cell Carcinoma
- Interventions
- Cabozantinib tablets, Everolimus (Afinitor) tablets
- Lead sponsor
- Exelixis
- Results first posted
- 2017-07-18
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01865747?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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