Comparison · NCT01922011-8ff00043
Daptomycin vs Vancomycin or Nafcillin: Number of Participants With 1 or More Adverse Events (AEs)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Daptomycin vs Vancomycin or Nafcillin: Number of Participants With 1 or More Adverse Events (AEs). Trial comparisons, record NCT01922011-8ff00043. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01922011-8ff00043
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.459 | 0.351 | 0.572 | wilson | |
| Risk in group 2 | 0.625 | 0.51 | 0.728 | wilson | |
| Risk difference, group 1 minus group 2 | -0.166 | -0.315 | -0.00417 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.735 | 0.542 | 0.997 | log | |
| Odds ratio, group 1 over group 2 | 0.51 | 0.263 | 0.988 | log | |
| Number needed to treat, for one fewer participant with the outcome on Daptomycin than on Vancomycin or Nafcillin | 6.04 | 3.17 | 240 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Daptomycin | IV daptomycin 7, 9, or 12 mg/kg once daily and ≤3 dummy infusions daily. | 34 | 74 | OG000 |
| Group 2 | Vancomycin or Nafcillin | IV vancomycin (or equivalent), 10 to 15 mg/kg q6h, or IV nafcillin (or β-lactam equivalent) 100-200 mg/kg/day, in divided doses q6h | 45 | 72 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- OTHER_PRE_SPECIFIED
- Title
- Number of Participants With 1 or More Adverse Events (AEs)
- Description
An AE is any untoward medical occurrence in a participant administered a pharmaceutical product and which does not necessarily have to have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign, clinically significant laboratory finding, symptom, or disease temporally associated with the use of a medicinal product, whether or not considered related to the medicinal product
- Time frame
- Administration of first dose up to approximately six and a half months after last dose of study drug
- Population
- Treated participants based on the treatment received
Source ClinicalTrials.gov
Trial
- Title
- Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006)
- NCT number
- NCT01922011
- Phases
- PHASE3
- Conditions
- Acute Hematogenous Osteomyelitis
- Interventions
- Daptomycin, Vancomycin (or equivalent), Nafcillin (or equivalent)
- Lead sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
- Results first posted
- 2017-06-23
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01922011?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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