Comparison · NCT01922011-sae
Daptomycin vs Vancomycin or Nafcillin: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Daptomycin vs Vancomycin or Nafcillin: serious adverse events. Trial comparisons, record NCT01922011-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01922011-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0676 | 0.0292 | 0.149 | wilson | |
| Risk in group 2 | 0.0556 | 0.0218 | 0.134 | wilson | |
| Risk difference, group 1 minus group 2 | 0.012 | -0.0756 | 0.0998 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.22 | 0.34 | 4.35 | log | |
| Odds ratio, group 1 over group 2 | 1.23 | 0.317 | 4.78 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Daptomycin than on Vancomycin or Nafcillin | 83.2 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Daptomycin | IV daptomycin 7, 9, or 12 mg/kg once daily and ≤3 dummy infusions daily | 5 | 74 | EG000 |
| Group 2 | Vancomycin or Nafcillin | IV vancomycin (or equivalent), 10 to 15 mg/kg q6h, or IV nafcillin (or β-lactam equivalent) 100-200 mg/kg/day, in divided doses q6h. | 4 | 72 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Serious Adverse Events (AEs): Up to approximately six and a half months after last dose of study drug. Non-serious AEs (NSAEs): Up to 35 days after last dose of study drug
Source ClinicalTrials.gov
Trial
- Title
- Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006)
- NCT number
- NCT01922011
- Phases
- PHASE3
- Conditions
- Acute Hematogenous Osteomyelitis
- Interventions
- Daptomycin, Vancomycin (or equivalent), Nafcillin (or equivalent)
- Lead sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
- Results first posted
- 2017-06-23
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01922011?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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