Comparison · NCT01924533-122cdf6f
Olaparib 100 mg Tablets bd + Paclitaxel 80 mg/m^2 vs Placebo Tablets bd + Paclitaxel 80 mg/m^2: Number of Patients With Objective Response.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Olaparib 100 mg Tablets bd + Paclitaxel 80 mg/m^2 vs Placebo Tablets bd + Paclitaxel 80 mg/m^2: Number of Patients With Objective Response. Trial comparisons, record NCT01924533-122cdf6f. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01924533-122cdf6f
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.167 | 0.127 | 0.217 | wilson | |
| Risk in group 2 | 0.107 | 0.075 | 0.15 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0604 | 0.00135 | 0.12 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.57 | 1.01 | 2.44 | log | |
| Odds ratio, group 1 over group 2 | 1.68 | 1.01 | 2.79 | log | |
| Number needed to treat, for one more participant with the outcome on Olaparib 100 mg Tablets bd + Paclitaxel 80 mg/m^2 than on Placebo Tablets bd + Paclitaxel 80 mg/m^2 | 16.5 | 8.36 | 742 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Olaparib 100 mg Tablets bd + Paclitaxel 80 mg/m^2 | Olaparib 100 mg tablets bd + Paclitaxel 80 mg/m\^2 | 44 | 263 | OG000 |
| Group 2 | Placebo Tablets bd + Paclitaxel 80 mg/m^2 | Placebo tablets bd + Paclitaxel 80 mg/m\^2 | 28 | 262 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Patients With Objective Response.
- Description
Number of patients with objective response. Per RECIST 1.1, complete response (CR) is disappearance of all target lesions since baseline; partial response (PR) is at least a 30% decrease in the sum of the diameters of target lesions. Overall Response = CR + PR.
- Time frame
- Scans taken at baseline and then follow up assessments taken every 8 weeks up to Week 40 and then every 16 weeks until objective disease progression as defined by RECIST 1.1, assessed up to 3 years
- Population
- Full analysis set population
Source ClinicalTrials.gov
Trial
- Title
- Efficacy and Safety Study of Olaparib in Combination With Paclitaxel to Treat Advanced Gastric Cancer.
- NCT number
- NCT01924533
- Phases
- PHASE3
- Conditions
- Gastric Cancer
- Interventions
- Olaparib, Paclitaxel, Placebo
- Lead sponsor
- AstraZeneca
- Results first posted
- 2018-11-07
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01924533?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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