Comparison · NCT01951950-83d17fd6
Nicardipine vs Esmolol: Failure of Drug to Control Systolic Blood Pressure (SBP) < 140 mmHg
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Nicardipine vs Esmolol: Failure of Drug to Control Systolic Blood Pressure (SBP) < 140 mmHg. Trial comparisons, record NCT01951950-83d17fd6. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01951950-83d17fd6
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.05 | 0.00888 | 0.236 | wilson | |
| Risk in group 2 | 0.55 | 0.342 | 0.742 | wilson | |
| Risk difference, group 1 minus group 2 | -0.5 | -0.696 | -0.221 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.0909 | 0.0129 | 0.64 | log | |
| Odds ratio, group 1 over group 2 | 0.0431 | 0.00479 | 0.387 | log | |
| Number needed to treat, for one fewer participant with the outcome on Nicardipine than on Esmolol | 2 | 1.44 | 4.53 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Nicardipine | Subjects will receive a 15 mcg/kg bolus of nicardipine as needed followed by an infusion initiated at 5 mg/hr. Nicardipine may be titrated every 5 minutes, increasing 5 mg/hr and administering 15 mcg/kg bolus every minute to a maximum dose of 15 mg/hr. If SBP is not maintained \< 140 mmHg 5 minutes after achieving the maximum dose of nicardipine, medication failure will be declared and rescue drug (medication to be determined per anesthesiologist discretion) will be administered. Infusions may be titrated down if SBP decreases below 90 mmHg. | 1 | 20 | OG000 |
| Group 2 | Esmolol | Subjects will receive a 0.5 mg/kg bolus of esmolol as needed followed by an infusion initiated at 50 mcg/kg/min. Esmolol may be titrated every 5 minutes, increasing 50 mcg/kg/min and administering 0.5 mg/kg bolus every minute to a maximum dose of 200 mcg/kg/min. If SBP is not maintained \< 140 mmHg 5 minutes after achieving the maximum dose of esmolol, medication failure will be declared and rescue drug (medication to be determined per anesthesiologist discretion) will be administered. Infusions may be titrated down if SBP decreases below 90 mmHg. | 11 | 20 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Failure of Drug to Control Systolic Blood Pressure (SBP) < 140 mmHg
- Description
- Time frame
- 1 hour postoperatively
- Population
Source ClinicalTrials.gov
Trial
- Title
- Nicardipine vs Esmolol Craniotomy Emergence
- NCT number
- NCT01951950
- Phases
- PHASE1
- Conditions
- Brain Tumors
- Interventions
- Nicardipine, Esmolol
- Lead sponsor
- Northwestern University
- Results first posted
- 2014-08-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01951950?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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